![]() ![]() reported a curvilinear relationship between the decibel differential light sensitivity and both the pattern electroretinogram amplitude and neuroretinal rim area, as well as a linear relationship between 1/Lambert differential light sensitivity and the pattern electroretinogram amplitude and neuroretinal rim area. However, a nonlinear function for describing the structure-function relationship was suggested to be better than linear functions, using a confocal laser ophthalmoscope and time-domain (TD) optical coherence tomography (OCT) to quantify the structures. reported that the coefficient of correlation between visual field (VF) mean deviation (MD) and average retinal nerve fiber layer (RNFL) thickness was 0.79 and that this structure-function relationship was primarily investigated using linear regression analysis. Many studies have reported various results for this topic, depending on the imaging techniques and statistical methods used, as well as the subject groups investigated and other factors. However, as Hood and Kardon mentioned, there is no consensus regarding the relationship between the functional loss of sensitivity to light and the structural loss of retinal ganglion cell axons. Glaucoma is a progressive optic neuropathy characterized by structural changes of the optic nerve and retina that are associated with visual functional defects. Glaucoma Retinal nerve fiber layer Visual fields The thickness of the RNFL had a negative logarithmic correlation with the VF indices and was more relevant to the VF indices than the area of the RNFL defect, as measured by OCT. In the severe stage of VF damage, correlation between the area of the RNFL defect and mean deviation was significantly greater than in other stages (partial Spearman correlation coefficient, -0.66 p = 0.02). Multiplication of the area and the inverted RNFL thickness showed a moderately correlated logarithmic relationship with the VF indices (partial Spearman correlation coefficient, 0.46 95% confidence interval, 0.34 to 0.57 p < 0.0001). Many outliers were detected in the Lowess-plotted graphs. The area of the RNFL defect showed a weak correlation with the pattern of standard deviation, whereas the remnant RNFL thickness was moderately correlated with the pattern of standard deviation (partial Spearman correlation coefficient, 0.39, -0.47, respectively p < 0.0001). Age, optic disc size, refraction, central corneal thickness and the presence of systemic disease were corrected for in order to exclude confounding factors.Ī logarithmic scale of RNFL thickness showed a negative linear relationship with VF indices. The differences between these associations depending on the stage of VF damage were further analyzed. The relationships between the RNFL thickness or area of the defect and visual field (VF) indices were assessed using the Lowess function, regression analysis and partial Spearman correlation. The thickness of retinal nerve fiber layer (RNFL) around the optic disc and the area of RNFL defect were determined using OCT scans. In total, 190 patients with normal tension glaucoma or primary open angle glaucoma were included in this study. To evaluate the relationship between the structural damage as assessed by time-domain optical coherence tomography (OCT) and functional changes in glaucoma. Tel: 82-2-3410-3564, Fax: 82-2-3410-0074, 8 2014 22 7 2014 28 4 323 329 23 10 2013 20 12 2013 © 2014 The Korean Ophthalmological Society 2014 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, #81 Irwon-ro, Gangnam-gu, Seoul 135-710, Korea. 3Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Ĭorresponding Author: Changwon Kee, MD, PhD. Korean J Ophthalmol Korean J Ophthalmol KJO Korean Journal of Ophthalmology : KJO 1011-8942 2092-9382 The Korean Ophthalmological Society 25120341 4120353 10.3341/kjo.2014.28.4.323 Original Article Depth and Area of Retinal Nerve Fiber Layer Damage and Visual Field Correlation Analysis Suh Wool 1 Lee Jung Min 2 Kee Changwon 3 1Department of Ophthalmology, Dongtan Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, Korea.
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